Project Title: Severe Neonatal Infection Adaptive Platform Trials in Africa

Project Description: The goal of SNIP-AFRICA is to establish a clinical research network to implement adaptive platform trials in sub- Saharan Africa (SSA) responding to the urgent need for improved treatment of neonatal sepsis in the context of increasing antimicrobial resistance. SNIP-AFRICA will achieve this aim by bringing together partners with experience in designing and running randomized controlled trials (RCTs) in SSA, including adaptive platform trials, engaging in care for neonatal patients in rural and urban settings,... The goal of SNIP-AFRICA is to establish a clinical research network to implement adaptive platform trials in sub- Saharan Africa (SSA) responding to the urgent need for improved treatment of neonatal sepsis in the context of increasing antimicrobial resistance. SNIP-AFRICA will achieve this aim by bringing together partners with experience in designing and running randomized controlled trials (RCTs) in SSA, including adaptive platform trials, engaging in care for neonatal patients in rural and urban settings, building on existing expertise and capacity to enable a rapid response to this major health threat. It will address all aspects from defining potential treatments of interest to translation into policy and will deliver interventional studies in the treatment domains of neonatal dose identification and empiric antibiotic treatment selection. Although SNIP-AFRICA would focus on neonates, the network could be readily extended to include infants and older children in the future. SNIP AFRICA overarching objectives include; 1. Build a sustainable platform and governance structure 2. Implement of an adaptive trial in the ‘drug-regimen’ domain 3. Conduct pharmacokinetic studies in the ‘dose’ domain 4. Lead on-going surveillance of neonatal sepsis epidemiology and management 5. Train on adaptive platform trials and neonatal sepsis 6. Engage with families, clinicians, and regulators to assess acceptability and feasibility of an adaptive platform trial in SSA neonatal care. Read more

Principal Investigator : Getrude Joseph Mollel

Department Name :

Time frame: (2023-07-01) - (2028-06-30)

Funding Partners
European Union (EU) Horizon 2020 (Normal)
Fondazione Penta Ets (Prime)
External Collaborating Partners
None added yet.